Repurposing Antidiabetic Drugs against Respiratory Syncytial Viral Infection: A Docking Study

Respiratory Syncytial Viral Infection is one of the most common viral infections in respiratory airways and more infants, younger children some adults. Although ribavirin has been used management RSV infection, many effective drugs are still under development. Also, structured based drug design using computational tools shifted paradigm discovery. The fusion core (RSV) structure crucial for its fusion, entry replication host cell. Herein, we investigated interruption formation and/or stability core. 15 ligands were screened 4 (Glimepiride, Glipizide, Canagloflozin, Glibenclamide) them potential candidate experimental validation, preclinical trials, clinical trials route administration optimization. To best our knowledge, this first time reporting lead molecules against from oral hypoglycemic agents. It also suggests consideration as prophylactics infants adults via inhalation route.